Polyunsaturated Fatty Acids Mediated Regulation of Membrane Biochemistry and Tumor Cell Membrane Integrity
نویسندگان
چکیده
منابع مشابه
Polyunsaturated fatty acids, membrane organization, T cells, and antigen presentation.
Dietary supplementation with polyunsaturated fatty acids (PUFAs), especially those of the n-3 class, has immunosuppressive effects on both innate and adaptive immunity through various mechanisms. In this review, we focus on the PUFA modulation of membrane architecture and its consequent effects on both T cell responses and antigen presentation. We first use data from in vitro and in vivo experi...
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All living cells, prokaryotic and eukaryotic, have a plasma membrane that encloses their contents and serves as a semi-porous barrier to the outside environment. The basic matrix of the plasma membrane consists essentially of two sheets (a bilayer) of phospholipids molecules. Among the significant components of cell membranes are the phospholipids, which contain fatty acids. The types of fatty ...
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Docosahexaenoic acid (DHA) and arachidonic acid (ARA) are important structural components of the central nervous system. These fatty acids are transferred across the placenta, are present in human milk, and are accumulated in the brain and retina during fetal and infant development. The high concentrations of DHA in the retina and of DHA and ARA in brain gray matter suggests that these fatty ac...
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Polyunsaturated fatty acids (PUFAs) exert immunosuppressive effects, but the molecular alterations leading to T cell inhibition are not yet elucidated. Signal transduction seems to involve detergent-resistant membrane domains (DRMs) acting as functional rafts within the plasma membrane bilayer with Src family protein tyrosine kinases being attached to their cytoplasmic leaflet. Since DRMs inclu...
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BACKGROUND The levels of erythrocyte polyunsaturated fatty acids (FAs) may be associated with obesity, metabolic syndrome, and cancer. Thus, we investigated the association between erythrocyte n-3 and n-6 FA composition, body mass index (BMI), and biochemical profiles. METHODS The body composition, dietary intake, and blood parameters, including serum lipid, glucose, insulin, adipokines, oxid...
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ژورنال
عنوان ژورنال: Membranes
سال: 2021
ISSN: 2077-0375
DOI: 10.3390/membranes11070479